TCAP’s in Peer Review Literature

The first commercial application for a neurologic molecule family that has been studied for 12 years

Hogg DW, Chen Y, D’Aquila AL, Xu M, Husić M, Tan LA, Bull C, Lovejoy DA (2018) A novel role of the corticotropin-releasing hormone regulating peptide, teneurin C-terminal associated peptide 1, on glucose uptake in the brain. Journal of Neuroendocrinology.Apr;30(4):e12579. doi: 10.1111/jne.12579

D’Aquila AL, Hsieh AH, Hsieh AH, De Almeida R, Lovejoy SR, Lovejoy DA  (2017) Expression and actions of corticotropin-releasing factor/diuretic hormone-like peptide (CDLP) and teneurin C-terminal associated peptide (TCAP) in the vase tunicate, Ciona intestinalis: Antagonism of the feeding response. General and Comparative Endocrinology. May 15:246. doi: 10.1016/j.ygcen.2016.06.015

Colacci M, De Almeida R, Chand D, Lovejoy SR, Sephton D, Vercaemer B, Lovejoy DA (2015) Characterization of the teneurin C-terminal associated peptide (TCAP) in the vase tunicate, Ciona intestinalis: A novel peptide system associated with energy metabolism and reproduction. General and Comparative Endocrinology. May 15;216:161-70. doi: 10.1016/j.ygcen.2015.01.021

Lovejoy, DA, Pavlovic, T (2015) Teneurins and teneurin C-terminal associated peptides (TCAP): A new mechanism underlying reproduction. Hormone Molecular Biology and Clinical Investigation  doi: 10.1515/hmbci-2015-0032.

Woelfle R., D’Aquila, AL, Lovejoy D.A. (2016) Teneurins, Teneurin C-terminal associated peptides (TCAP) and latrophilins: A role in the etiology of mood disorders. Translational Neuroscience Apr 24;9:146. doi: 10.3389/fnins.2015.00146.

Woelfle, R. D’Aquila, AL., Husic M., Pavlovic, T, Lovejoy, DA (2015) Ancient interaction between the teneurin C-terminal associated peptides (TCAP) and latrophilin ligand-receptor coupling: A role in behavior Frontiers in Neuroscience 9:146 (doi: 10.3389/fnins.2015.00146)

Erb S, McPhee M, Brown ZJ,  Kupferschmidt DA, Song L, Lovejoy DA (2014)  Repeated intraveneous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats  Behavioral Brain Research 269, 1-5 doi: 10.1016/j.bbr.2014.04.013

Chen Y, Xu M,   De Almeida R, Lovejoy DA (2013) Teneurin C-terminal associated peptides (TCAP): Modulators of corticotropin-releasing factor (CRF) physiology and behaviour. Frontiers in Neuroscience 7, 166 doi10.3389/fnins.2013.00166.

Chand, D., Colacci, M., Dixon, K., Kollara, A., Brown, T.J. Lovejoy, D.A. (2013) C-terminal region of teneurin-1 co-localizes with the dystroglycan complex in the seminiferous tubules and epididymis of the adult mouse testes and regulates testicular size and testosterone production. Histochemistry and Cell Biology 141:191-211.

Chand, D; Casatti,CA, DeLannoy, L.,  Song L; Kollara A,  Barsyte-Lovejoy, D;  Brown TJ; Lovejoy, DA  (2013) C-terminal processing of the teneurin proteins: Independent actions of a teneurin C-terminal associated peptide in hippocampal cells.  Molecular and Cellular Neuroscience 52,38-50.

Chand D, Song L.,de Lannoy, L., Barsyte-Lovejoy, D., Ackloo S., Boutros, P.C., Evans, K., Belsham, Lovejoy, D.A. (2012) C-terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an ERK-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells. Neuroscience 219,255-270

Tan, LA, Chand, D.,  De Almeida R, Xu, M, Colacci, M, De Lannoy, L, Lovejoy DA (2012) Modulation of neuroplastic changes and corticotropin-releasing factor associated behaviour by a phylogenetically ancient and conserved peptide family. General and Comparative Endocrinology. 176,309-313.

Ng. T., Chand D., Song L., Watson JD., Boutros P.C., Barsyte-Lovejoy, D., Belsham DD., Lovejoy DA (2011) Identification of a novel Brain Derived Neurotrophic Factor (BDNF)-inhibitory factor: Regulation of BDNF by Teneurin C-terminal Associated Peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells Regulatory Peptides 174, 79-89.

Tan, L.A., Al Chawaf, A., Vaccarino, F.J, Boutros, J.C., Lovejoy, D.A. (2011) Teneurin C-terminal associated peptide (TCAP)-1 increases dendritic spine density in hippocampal neurons and decreases anxiety-like behaviors in rats Physiology and Behavior  104, 199-204.

Kupferschmidt, D., Lovejoy DA., Rotzinger S., Erb, S. (2011) Teneurin C-terminal associated peptide (TCAP)-1 blocks the effects of  corticotropin-releasing factor (CRF) on the reinstatement of cocaine seeking and expression of cocaine-induced behavioral sensitization British Journal of Pharmacology  163, 574-583

Rotzinger, S, Lovejoy DA, Tan L (2010) Behavioral effects of neuropeptide ligands in rodent models of depression and anxiety Peptides 31, 736-756

Tan L., Lovejoy DA (2009) Neuroprotection, neuronal remodelling, and anxiety-like behaviour: The role of the teneurin and  teneurin C-terminal associated peptide (TCAP) system in the hippocampus. American Journal of Neuroprotection and Neuroregeneration. 1: 3-10

Tan L, Xu K, Vaccarino FJ, Lovejoy  DA,  Rotzinger S (2009) Teneurin C-terminal associated peptide (TCAP)-1 attenuates corticotropin-releasing factor (CRF)-induced c-Fos expression in the limbic system and modulates anxiety behaviour in male Wistar rats Behavioural Brain Research 201, 198-206

Lovejoy DA, Rotzinger S, Barsyte-Lovejoy, D (2009) Evolution of complementary peptide systems: Teneurin C-terminal associated peptide (TCAP) and corticotropin-releasing factor (CRF) superfamilies. Annals of the New York Academy of Sciences. 1163, 215-220.

Tan L., Xu K., Vaccarino F, Lovejoy DA, Rotzinger S. (2008) Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety. Behavioural Brain Research 188, 195-200.

Trubiani,G, Al Chawaf, A., Belsham, D.D.,  Barsyte-Lovejoy, D. Lovejoy, D.A.(2007) Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic cell death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells. Brain Research  1176,27-36.

Al Chawaf A., Xu, K., Tan L., Vaccarino F., Lovejoy, DA and Rotzinger S (2007) Corticotropin-releasing factor behaviours are modulated by intravenous administration of teneurin C-terminal associated peptides. Peptides 28, 1406-1415. This paper won the 2007 Gayle A. Olson and Richard D. Olson Prize for the most meritorious original research article on the behavioural effects of peptides published in ‘Peptides’ in 2007

Cheran LE, Cheung S, Al Chawaf A, Ellis JS, Belsham DD, Lovejoy DA, Thompson M (2007) Label-free detection of neuron drug interactions using acoustic and Kelvin vibrational fields. The Analyst 132; 242-255

Al Chawaf A, St. Amant, K, Belsham DD, Lovejoy DA (2007) Regulation of neurite outgrowth in immortalized hypothalamic cells and hippocampal primary cultures by teneurin C-terminal associate peptide-1 (TCAP-1).  Neuroscience 144, 1241-1254.

TCAP’s have been referenced in an increasing number of peer-review publications in recent years.