TCAP: The body’s natural brake to the stress flywheel

Teneurin C-Terminal Associated Peptides (TCAPs) work on nerve receptors in brain regions controlling fear, stress, memory, and emotion. TCAP modulates the Corticotropin Releasing Factor (CRF) signaling system, the key driver of stress response in the human brain and body.

PT00114: PTI’s patent-protected version of TCAP-1

Our studies have shown evidence that PT00114 is a strong regulator of stress response in key neuronal pathways in the brain. In addition, PT00114 shows evidence of improving function of neuronal cells. Because this mechanism is similar across different animal species and humans, we believe that our experimental observations can form the basis for our molecule to work by profoundly improving neuronal health. Such a regulation of energy metabolism in the brain formed the impetus for us to pursue various stress-related disorders as a first set of potential indications.

Our studies have shown evidence that PT00114 is a strong regulator of cellular metabolism, including neuronal cells.