Teneurin C-terminus Associated Peptides (TCAPs) were identified in fish brains ~20 years ago and subsequently found in every animal brain studied—from nematodes to humans.
Implicated in essential cellular functions
TCAPs play a role on several processes, including neuronal development, regulation of the stress response, glucose metabolism, cell adhesion and overall energy balance.
Modulates stress response
TCAP-1 inhibits ACTH release, which lowers cortisol downstream. This mitigates stress response and restores normal brain and body function.
Foundation for analog development
An analog of TCAP-1, PT00114 is a Protagenic first-in-class stress disorder treatment.
What is the promise?
PT00114 is low risk and high impact. It targets stress at its neurochemical roots—without the side effects. It transforms the treatment of acute and chronic stress-related disorders:
✕ No sedation
✕ No dependency
How we're doing it
Protagenic is developing PT00114 to address Anxiety, PTSD, Depression (MDD/TRD) and Substance Use Disorders. Our planned Phase II trial will evaluate efficacy in humans and is on track to enroll in 2026.
